A set of twenty recently published studies provides further support for the genetic link between the substance filaggrin and the skin disease, [tag-tec]eczema[/tag-tec], which is the most common skin disorder of industrialized nations.

The filaggrin gene normally makes large amounts of filaggrin protein in the outer layers of the skin, the epidermis. The filaggrin protein is responsible for maintaining appropriate skin barrier function.

A good skin barrier prevents the skin from drying out, and also keeps foreign substances from invading the body. In people with eczema, the filaggrin gene has been turned down or shut off, so their skin barrier does not function as it sould.

Research suggests that this turned off [tag-tec]filaggrin[/tag-tec] gene may effect up to 10 percent of those in European populations.

Decreased protein production by the filaggrin gene is also linked to other allergic conditions, including a certain type of asthma which frequently follows [tag-ice]eczema[/tag-ice] in patients, as well as in eczema-associated hay fever and other allergic symptoms.

With the identification of the [tag-ice]filaggrin[/tag-ice] gene, scientists can now find ways to turn the gene back on, so it produces enough protein to provide appropriate skin barrier protection; offering, perhaps, a long term solution to the itch of eczema.

Share This